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In bodybuilding, Nolvadex (Tamoxifen Citrate) is used as both an anabolic steroid cycle ancillary drug and as recovery or as a post anabolic steroid cycle therapy drug. At a low dosage, Nolvadex increases protein synthesis and muscle protein synthesis rates. At very high dosages, Nolvadex increases mitochondrial permeability transition protein which is required in maintaining muscle mass/strength. In addition, Nolvadex, in addition to the anti-aging effects, increases the activity of the antioxidant enzyme, superoxide dismutase by up to 100 times. It also protects against free radical damage induced by exercise [1]. In a clinical trial for patients with myopathically progressive, advanced prostate cancer, Nolvadex was found to be superior to placebo[2].

Prostate cancer patients are especially at risk of increased cancer-suppressing doses of the anti-aging drug, Nolvadex. Nolvadex has been shown to reduce cell death[3] and reduce the level of proteinuria in patients receiving therapy with high doses of estrogen[4]. In a study with mice, Nolvadex was found to extend lifespan compared to the control group[5]. However, in addition to extending lifespan in humans (by as much as 20% in both men and women), Nolvadex has also been found to be efficacious in lowering serum prostate-specific antigen (PSA) levels, a marker of prostate cancer risk in men [2].

With the development of new chemo-prophylaxis drugs, such as Nolvadex, chemo-therapy drugs for patients already receiving these drugs may be particularly helpful in improving their prognosis.

Cautions and side effects

In the current US (or European) drug approval process for drugs for the treatment of benign prostatic hyperplasia (BPH) there is a strict policy requiring that all data supporting the safety and effectiveness of a new drug, have been published in a peer-reviewed, systematic review and clinical data published in a high quality, peer-reviewed journal. In the case of Nolvadex, this is a requirement for all approved drugs submitted for approval as a treatment for BPH. Furthermore, in the case of the latest drug approvals, no approval data is required to support the safety and efficacy of this drug beyond peer-reviewed, systematic review data and clinical data published in high quality, peer-reviewed journals [6].

Citation

Nolvadex: Prostate cancer treatment for men http://www.clinicaltrials.gov/ct2/show/NCT

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