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Anabolic steroids may increase sensitivity to anticoagulants; therefore, dosage of an anticoagulant may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level. Therapy with androgenic anabolic steroids may decrease levels of thyroxine-binding globulin resulting in decreased total T 4 serum levels and increase resin uptake of T 3 and T 4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Carcinogenesis, Mutagenesis, Impairment of Fertility. Animal data: Testosterone has been tested by subcutaneous injection and implantation in mice and rats, natural bodybuilding at 60. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. 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