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Table 1 describes adverse reactions (Grades 1-4 and Grade 3-4) irrespective of relationship to study treatment in the adjuvant trial for the monotherapy arms analysis (safety population). Table 1: Patients with Adverse Reactions (CTC Grades 1-4,) in the Adjuvant Study ‘ Monotherapy Arms Analysis (Median Follow-up 96 Months; Median Treatment 60 Months) Grades 1-4 Grades 3-4 Adverse Reactions Letrozole tablets N=2448 n (%) Tamoxifen N=2447 n (%) Letrozole tablets N=2448 n (%) Tamoxifen N=2447 n (%) Patients with any adverse reaction 2309 (94. When considering all grades during study treatment, a higher incidence of events was seen for Letrozole tablets regarding fractures (10. A higher incidence was seen for tamoxifen regarding thromboembolic events (2. At a median follow up of 96 months, a higher incidence of events was seen for Letrozole tablets (14. A higher incidence was seen for tamoxifen compared to Letrozole tablets regarding thromboembolic events (4. Bone Study: Results of a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer in the adjuvant setting comparing the effect on lumbar spine (L2-L4) BMD of adjuvant treatment with Letrozole to that with tamoxifen showed at 24 months a median decrease in lumbar spine BMD of 4. In another postapproval randomized, multicenter, open label, study of Letrozole vs anastrozole in the adjuvant treatment of postmenopausal women with hormone receptor and node positive breast cancer (FACE, NCT00248170), the median duration of treatment was 60 months for both treatment arms. Table 2 describes adverse reactions (Grades 1-4 and Grades 3-4) irrespective of relationship to study treatment in the adjuvant study (safety population). Table 2: Adverse Reactions (CTC Grades 1-4), Occurring in at least 5% of Patients in Either Treatment Arm, by Preferred Term (Safety set) Adverse Reactions Letrozole N=2049 n (%) Anastrozole N=2062 n (%) Grade 3/4 n (%) All grades n (%) Grade 3/4 n (%) All grades n (%) Patients with at least one AR 628 (30. Extended Adjuvant Treatment of Early Breast Cancer, Median Treatment Duration of 24 Months. In study MA-17, the median duration of extended adjuvant treatment was 24 months and the median duration of follow-up for safety was 28 months for patients receiving Letrozole tablets and placebo. Table 3 describes the adverse reactions occurring at a frequency of at least 5% in any treatment group during treatment. Most adverse reactions reported were Grade 1 and Grade 2 based on the Common Toxicity Criteria Version 2. In the extended adjuvant setting, the reported drug-related adverse reactions that were significantly different from placebo were hot flashes, arthralgia/arthritis, and myalgia. Table 3: Adverse Reactions Occurring in at least 5% of Patient in either Treatment Arm. Number (%) of Patients with Grade 1-4 Adverse Reaction Number (%) of Patients with Grade 3-4 Adverse Reaction Letrozole tablets N=2563 Placebo N=2573 Letrozole tablets N=2563 Placebo N=2573 Any Adverse Reaction 2232 (87. The incidence of self-reported osteoporosis was higher in patients who received Letrozole tablets 6. Bisphosphonates were administered to 21, trenbolone 75 mg injectable steroids $52.00 trenbolone acetate. undefined 200 – 400 mg per week (injections once every 4 – 7 days). 1997 · цитируется: 52 — the effects of the growth-promoting steroids estradiol-17 beta (e2), trenbolone acetate (tba), and melengestrol acetate (mga) in heifers on serum. Infarction (mi) following chronic trenbolone acetate consumption. 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