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It didn’t take long for people to realize how using testosterone would help athletes. In 1954, the American Weightlifting Team began using test and the team’s doctor, John Ziegler, began working with pharmaceutical companies to refine the substance to be more efficient in enhancing strength. In 1967, AAS were banned by the International Olympic Council (IOC) and many sport organizations began following suit. This was the beginning of the ever-continuing struggle between sports organizations and the athletes. Soon, the IOC had a test to determine if athletes had used testosterone, but it didn’t take long for the athletes to develop different types of drugs that would work around the tests ‘ the first being a steroid that would leave the body quickly so that it wouldn’t so up on the drug test. Perhaps the most adept at this was the German Democratic Republic who conducted much of the research in how to use AAS and still remain undetected. Amazingly, the fact that the government was both research and concealing steroid use in the country’s athletes remained unknown until the late 80’s. This scandal is what has given steroids a bad name. Ironically, however, this is about the same time that the medical community found the benefits of using AAS for medical purposes in the treatment of certain illnesses and ailments. AAS are not out of the public light yet, however. We mostly hear about them being used as performance enhancing drugs when professional athletes test positive for using the substance. AAS are still being widely used in the United States ‘ for both medical purposes as well as by athletes and bodybuilders. Anabolic steroids are a class of steroid hormones that are based on testosterone. Also known as anabolic androgenic steroids (AAS) or colloquially as “steroids”, these drugs mimic the effects of dihydrotestosterone (DHT) and testosterone in the body. The use of AAS is related to an increase in protein synthesis, a process in which body cells manufacture proteins, within the body cells to build up cellular tissue, especially in the muscles. These drugs have virilizing and androgenic properties that stimulate the development and maintenance of masculine features like growth of body hair and vocal cords, anabolic optimism. While these drugs were first synthesized in the year 1930, these days they are used under medical supervision for stimulating the growth of bones and improving appetite, as well as inducing male puberty and treating chronic wasting conditions. It is worthwhile to note that the use of AAS in combination with a proper bodybuilding diet and exercises can easily lead to muscle strength and performance gains. AAS use is also related to dramatic enhancements in terms of stamina, muscle function, muscle size, muscle definition, red blood cell count and nitrogen retention; in addition, they are used to gain or lose body weight. AAS are commonly available and administered in four common forms: oral pills, skin patches, injectable, and creams or gels for topical application. It is important to note that the traditional administration routes don’t have differential effects on efficiency of the drug, though some orals may lead to liver damage in rare cases. Generally, all water-based and oil-based anabolics should be taken using intramuscular injections, and the common sites for administering intramuscular injections are the deltoid region of the arm (shoulder), the buttock, and the lateral side of the thigh. Other injection sites that may be considered by you could include Biceps, Lats, Pectorals, Quadriceps, Traps, and Calves. AAS, as fat-soluble hormones, are membrane-permeable and have the potential of influencing the nucleus of cells by direction actions and their pharmacodynamic action gets initiated when membrane of the target cell is penetrated by the exogenous hormone and bind to an androgen receptor that is located in cytoplasm of the specific cell. After this, the compound hormone-receptor gets diffused into the nucleus after which it either activates processes that transmit signals to other parts of the cells or alter the expression of genes.
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